Yes. You can use If-So with the ACF plugin.
The first step is to create an If-So trigger and paste its shortcode inside the custom field. Since Advanced Custom Fields do not render shortcodes by default, next you’ll need to add the following filters to your functions.php file. Please feel free to contact us if you need help with that.
If you’d like to use If-So inside a Text field:
If you’d like to use If-So inside a Text Area field: